GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11921451 | 1 | rs11921451 | chr3:126787159 | CHST13 | chr3:126243176-126262133:+ | 0.15 | 3.47 | 0.000535 | Amyotrophic lateral sclerosis (sporadic) |
| BRCA | cis | rs10935120 | 1 | rs11927068 | chr3:134266321 | ANAPC13 | chr3:134196547-134204865:- | -0.41 | -13.19 | 6.77E-37 | Height |
| BRCA | cis | rs10935120 | 1 | rs11927068 | chr3:134266321 | CEP63 | chr3:134204575-134293852:+ | -0.14 | -3.72 | 0.000212 | Height |
| BRCA | cis | rs7647973 | 1 | rs11928090 | chr3:49604904 | AMT | chr3:49454212-49460012:- | 0.13 | 4.5 | 7.55E-6 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11928090 | chr3:49604904 | CCDC36 | chr3:49235861-49295537:+ | 0.11 | 4 | 6.76E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11928090 | chr3:49604904 | GMPPB | chr3:49758932-49761384:- | -0.12 | -3.45 | 0.000575 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11928090 | chr3:49604904 | NCKIPSD | chr3:48711280-48723334:- | 0.17 | 4.2 | 2.92E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11928090 | chr3:49604904 | P4HTM | chr3:49027341-49044579:+ | 0.09 | 3.99 | 7.03E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11928090 | chr3:49604904 | WDR6 | chr3:49044637-49053386:+ | -0.16 | -4.67 | 3.32E-6 | Menarche (age at onset) |
| BRCA | cis | rs10935120 | 1 | rs11928499 | chr3:134232350 | ANAPC13 | chr3:134196547-134204865:- | -0.41 | -13.41 | 4.97E-38 | Height |
| BRCA | cis | rs10935120 | 1 | rs11928499 | chr3:134232350 | CEP63 | chr3:134204575-134293852:+ | -0.15 | -4.06 | 5.32E-5 | Height |
| BRCA | cis | rs7692995 | 1 | rs11930105 | chr4:17972078 | NCAPG | chr4:17812525-17846485:+ | 0.1 | 4.5 | 7.38E-6 | Height |
| BRCA | cis | rs7692995 | 1 | rs11930366 | chr4:17960168 | NCAPG | chr4:17812525-17846485:+ | 0.09 | 4.31 | 1.81E-5 | Height |
| BRCA | cis | rs1109501 | 1 | rs11932207 | chr4:71330534 | AMTN | chr4:71384298-71398459:+ | 0.26 | 7.59 | 7.15E-14 | Alcoholism (heaviness of drinking) |
| BRCA | cis | rs7692995 | 1 | rs11933575 | chr4:17971138 | NCAPG | chr4:17812525-17846485:+ | 0.09 | 4.4 | 1.21E-5 | Height |